BDBM284431 4-(6-(4-(2,6- difluorobenzyl)piperazin- 1-yl)pyridine-3-yl)-6-(1- methyl-1H-pyrazol-4- yl)pyrazolo[1,5-a]pyridine- 3-carbonitrile::US10023570, Example 441::US10174028, Example 441

SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3c(F)cccc3F)CC2)c2c(cnn2c1)C#N

InChI Key InChIKey=VFYNKRKNZOXDIX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284431   

LigandPNGBDBM284431(US10023570, Example 441 | 4-(6-(4-(2,6- difluorobe...)
Affinity DataIC50: 4.70nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
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LigandPNGBDBM284431(US10023570, Example 441 | 4-(6-(4-(2,6- difluorobe...)
Affinity DataIC50: 12.5nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284431(US10023570, Example 441 | 4-(6-(4-(2,6- difluorobe...)
Affinity DataIC50: 4.70nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM284431(US10023570, Example 441 | 4-(6-(4-(2,6- difluorobe...)
Affinity DataIC50: 12.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284431(US10023570, Example 441 | 4-(6-(4-(2,6- difluorobe...)
Affinity DataIC50: 4.70nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM284431(US10023570, Example 441 | 4-(6-(4-(2,6- difluorobe...)
Affinity DataIC50: 12.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent