BDBM284526 4-(6-(2,9- diazaspiro[5.5]undecan-2- yl)pyridin-3-yl)-6-(1- methyl-1H-pyrazol-4- yl)pyrazolo[1,5-a]pyridine- 3-carbonitrile dihydrochloride::US10023570, Example 540::US10174027, Example 540

SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCCC3(CCNCC3)C2)c2c(cnn2c1)C#N

InChI Key InChIKey=XUUHOEDCXAKSHR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284526   

LigandPNGBDBM284526(US10023570, Example 540 | 4-(6-(2,9- diazaspiro[5....)
Affinity DataIC50: 5.10nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
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LigandPNGBDBM284526(US10023570, Example 540 | 4-(6-(2,9- diazaspiro[5....)
Affinity DataIC50: 52.3nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284526(US10023570, Example 540 | 4-(6-(2,9- diazaspiro[5....)
Affinity DataIC50: 5.10nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM284526(US10023570, Example 540 | 4-(6-(2,9- diazaspiro[5....)
Affinity DataIC50: 52.3nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284526(US10023570, Example 540 | 4-(6-(2,9- diazaspiro[5....)
Affinity DataIC50: 5.10nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM284526(US10023570, Example 540 | 4-(6-(2,9- diazaspiro[5....)
Affinity DataIC50: 52.3nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent