BDBM285770 US10080744, Example 3/37

SMILES C[C@H](NC(=O)c1cc(cc(c1)C1(CC1)C(F)(F)F)-c1sc(nc1CC1CCC1)-c1nnc(CC(C)(C)C(O)=O)o1)C(F)(F)F

InChI Key InChIKey=XCJRLBMWFMJJPA-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285770   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM285770(US10080744, Example 3/37)
Affinity DataKd:  4nMAssay Description:For the RORγt construct used in the ThermoFluor assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM285770(US10080744, Example 3/37)
Affinity DataIC50: 45nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent