BDBM285771 US10080744, Example 3/38
SMILES CC[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCC2)-c2nnc(CC(C)(C)C(O)=O)o2)c(C(F)F)c1F)C(F)(F)F
InChI Key InChIKey=ILHSEFVQHFQLRM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 285771
Affinity DataKd: 0.0380nMAssay Description:For the RORγt construct used in the ThermoFluor assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR&...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
Affinity DataKd: 0.0400nMAssay Description:Binding affinity to RORgammat (unknown origin) assessed as dissociation constant by thermal shift binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Binding affinity to recombinant human RORgammat transfected in human HEK293T cells incubated for 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+3nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in IL-17a productionMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inverse agonist activity at RORgammat in mouse whole blood assessed as reduction in IL-17a productionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Binding affinity to recombinant human RORbeta transfected in human HEK293T cells incubated for 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataKd: 4.48E+3nMAssay Description:Binding affinity to RORbeta (unknown origin) assessed as dissociation constant by thermal shift binding assayMore data for this Ligand-Target Pair