BDBM285777 (S)-3-(5-(5-(2,3-Dichloro-4-(N-(1,1,1-trifluorobutan-2-yl)sulfamoyl)phenyl)-4-(2-methoxy-2-methylpropyl)thiazol-2-yl)-1,3,4-oxadiazol-2-yl)-2,2-dimethylpropanoic Acid::US10080744, Example 4

SMILES CC[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC(C)(C)OC)-c2nnc(CC(C)(C)OC=O)o2)c(Cl)c1Cl)C(F)(F)F

InChI Key InChIKey=APXHDQATEGATDV-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285777   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM285777(US10080744, Example 4 | (S)-3-(5-(5-(2,3-Dichloro-...)
Affinity DataKd:  2.30nMAssay Description:For the RORγt construct used in the ThermoFluor assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM285777(US10080744, Example 4 | (S)-3-(5-(5-(2,3-Dichloro-...)
Affinity DataIC50: 25nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent