BDBM286977 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one::US10294223, Cpd No. 4::US11078199, Cpd 4::US9567334, Example 4::US9815834, Compound 4

SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1

InChI Key InChIKey=FHDKNSAADPLWFU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 286977   

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM286977(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Affinity DataIC50: 1.20nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Principia Biopharma

US Patent
LigandPNGBDBM286977(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Affinity DataIC50: 1.20nMAssay Description:The cell-based effects of FGFR inhibitors were determined by measuring inhibition of FGFR-dependent cell line growth. The cell lines SNU-16 was used ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM286977(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Affinity DataIC50: 2nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM286977(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Affinity DataIC50: 2nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM286977(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Affinity DataIC50: 2nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent