BDBM287542 1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(methylamino)-1,6-naphthyridin-2(1H)-one::US10294223, Cpd No. 144::US11078199, Cpd 144::US9567334, Example 144::US9815834, Compound 144

SMILES CNc1cc2n(CCOC3CN(C3)C(=O)C=C)c(=O)c(cc2cn1)-c1c(Cl)c(OC)cc(OC)c1Cl

InChI Key InChIKey=MUWNBQMOGBRDAG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 287542   

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM287542(1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2,6-d...)
Affinity DataIC50: 2nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM287542(1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2,6-d...)
Affinity DataIC50: 2nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Principia Biopharma

US Patent
LigandPNGBDBM287542(1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2,6-d...)
Affinity DataIC50: 2.10nMAssay Description:The cell-based effects of FGFR inhibitors were determined by measuring inhibition of FGFR-dependent cell line growth. The cell lines SNU-16 was used ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM287542(1-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-3-(2,6-d...)
Affinity DataIC50: 2.10nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent