BDBM288265 5-(7-Chloro-1H-indazol-5-yl)-8-methyl-2-propyl-6-::US10087185, Example 83

SMILES CCCc1nc2c(C)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F

InChI Key InChIKey=LESAPQNMDUOCKH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288265   

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288265(US10087185, Example 83 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent