BDBM288550 US10087188, Example 158::cis-4-[8-amino-1-(4- {[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3- yl]cyclohexane- carboxylic acid

SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CC[C@@H](CC1)C(O)=O

InChI Key InChIKey=YZLMBXMJXHFDPM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 288550   

TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM288550(cis-4-[8-amino-1-(4- {[4- (trifluoromethyl) pyridi...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of 6-His-tagged recombinant full length BTK (unknown origin) expressed in baculovirus-transfected Sf9 cells using Biotin-EQEDEPEGDYFEWLE-N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM288550(cis-4-[8-amino-1-(4- {[4- (trifluoromethyl) pyridi...)
Affinity DataIC50: 3.10nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM288550(cis-4-[8-amino-1-(4- {[4- (trifluoromethyl) pyridi...)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of BTK in human PBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed