BDBM289504 1-(4-(6-amino-5-(tri- fluoromethyl)pyridin-3- yl)-1-(3-morpholino- bicyclo[1.1.1]pentan-1- yl)-1H-imidazol-2-yl)- 2-methylpropan-1-ol::US10093664, Example 68

SMILES CC(C)C(O)c1nc(cn1C12CC(C1)(C2)N1CCOCC1)-c1cnc(N)c(c1)C(F)(F)F

InChI Key InChIKey=BURDQUKVCPYGRG-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 289504   

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM289504(US10093664, Example 68 | 1-(4-(6-amino-5-(tri- flu...)
Affinity DataKd:  13nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

TargetProtein delta homolog 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM289504(US10093664, Example 68 | 1-(4-(6-amino-5-(tri- flu...)
Affinity DataIC50: 2nMAssay Description:Inhibition of DLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM289504(US10093664, Example 68 | 1-(4-(6-amino-5-(tri- flu...)
Affinity DataIC50: 2nMAssay Description:Inhibition of DLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 13(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM289504(US10093664, Example 68 | 1-(4-(6-amino-5-(tri- flu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of LZK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed