BDBM289785 (E)-3-(3,5-Difluoro-4-((1R,3R)-2-((S)-3-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid::US10130617, Example 3

SMILES C[C@H](CF)CN3[C@H](C)Cc1c([nH]c2ccccc12)[C@H]3c4c(F)cc(/C=C/C(=O)O)cc4F

InChI Key InChIKey=STVQFMFTCUMADM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 289785   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM289785((E)-3-(3,5-Difluoro-4-((1R,3R)-2-((S)-3-fluoro-2-m...)
Affinity DataIC50: 400nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM289785((E)-3-(3,5-Difluoro-4-((1R,3R)-2-((S)-3-fluoro-2-m...)
Affinity DataIC50: 1.00E+3nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent