BDBM289842 N-((2S)-1-(6-chloro-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,3′-pyrrolidine]-1′-yl)-1-oxo-3-phenylpropan-2-yl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-7-carboxamide 1,1-dioxide::US10093683, Example 193

SMILES Clc1ccc2NC(=O)OC3(CCN(C3)C(=O)[C@H](Cc3ccccc3)NC(=O)c3ccc4NC(=O)CS(=O)(=O)c4c3)c2c1

InChI Key InChIKey=SEVXEKMYFTWDSC-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289842   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM289842(N-((2S)-1-(6-chloro-2-oxo-1,2-dihydrospiro[benzo[d...)
Affinity DataKi:  145nM ΔG°:  -9.32kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent