BDBM289880 2-Hydroxy-N-methyl-N-((R)-1-{6-[5- (2H-pyrazol-3-yl)-pyridin-2-yloxy]- naphthalen-2-ylmethyl}-pyrrolidin- 3-yl)-acetamide::US9573957, Example 21

SMILES CN([C@@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1)C(=O)CO

InChI Key InChIKey=GUTZEKQYDASHDN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289880   

TargetLeukotriene A-4 hydrolase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM289880(2-Hydroxy-N-methyl-N-((R)-1-{6-[5- (2H-pyrazol-3-y...)
Affinity DataIC50: 0.670nMpH: 7.5 T: 2°CAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
Go to US Patent