BDBM29013 4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]-N-[(2R)-5-(1H-1,2,3,4-tetrazol-1-yl)pentan-2-yl]benzene-1-sulfonamide::Nitrogen-appended N-alkylsulfonamide, 2

SMILES C[C@H](CCCn1cnnn1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=WFWGAWVCMNUSPE-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 29013   

LigandPNGBDBM29013(4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]-N-[(...)
Affinity DataEC50:  0.510nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM29013(4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]-N-[(...)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed