BDBM292067 US10100046, Example 2::US9902719, Example 2::cis-4-(2-{decahydropyrrolo[3,4-d]azepin-6- yl}-5-(1-methyl-1H-indazol-5-yl)-1,3- thiazol-4-yl)benzonitrile

SMILES Cn1ncc2cc(ccc12)-c1sc(nc1-c1ccc(cc1)C#N)N1CC[C@@H]2CNC[C@@H]2CC1

InChI Key InChIKey=XFPQLJHGYZUVNB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292067   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM292067(US10100046, Example 2 | cis-4-(2-{decahydropyrrolo...)
Affinity DataIC50: 100nMT: 2°CAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM292067(US10100046, Example 2 | cis-4-(2-{decahydropyrrolo...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent