BDBM294373 US9586959, Compound 104::US9586959, Compound 24::US9586959, Compound 68

SMILES CNC1CN(C1)c1nc2ncc(Br)cc2n2cnnc12

InChI Key InChIKey=MMVBKZHQTLDYKG-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 294373   

TargetHistamine H4 receptor(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294373(US9586959, Compound 24 | US9586959, Compound 68 | ...)
Affinity DataIC50: 36nMpH: 7.5 T: 2°CAssay Description:In vitro profiling protein kinases was performed using the HotSpot assay platform. Briefly, specific kinase/substrate pairs along with required cofac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetHistamine H4 receptor(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294373(US9586959, Compound 24 | US9586959, Compound 68 | ...)
Affinity DataIC50: 130nMpH: 7.5 T: 2°CAssay Description:In vitro profiling protein kinases was performed using the HotSpot assay platform. Briefly, specific kinase/substrate pairs along with required cofac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetHistamine H4 receptor(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294373(US9586959, Compound 24 | US9586959, Compound 68 | ...)
Affinity DataIC50: 30nMpH: 7.5 T: 2°CAssay Description:In vitro profiling protein kinases was performed using the HotSpot assay platform. Briefly, specific kinase/substrate pairs along with required cofac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294373(US9586959, Compound 24 | US9586959, Compound 68 | ...)
Affinity DataIC50: 1.00E+8nMpH: 7.4 T: 2°CAssay Description:Each compound of the present invention prepared in the examples was prepared in DMSO into concentrations of 0.02, 0.06, 0.3 and 2 mM. 10 uL of the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294373(US9586959, Compound 24 | US9586959, Compound 68 | ...)
Affinity DataIC50: 1.00E+8nMpH: 7.4 T: 2°CAssay Description:Each compound of the present invention prepared in the examples was prepared in DMSO into concentrations of 0.02, 0.06, 0.3 and 2 mM. 10 uL of the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294373(US9586959, Compound 24 | US9586959, Compound 68 | ...)
Affinity DataIC50: 1.00E+8nMpH: 7.4 T: 2°CAssay Description:Each compound of the present invention prepared in the examples was prepared in DMSO into concentrations of 0.02, 0.06, 0.3 and 2 mM. 10 uL of the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 3A(Human)
C&C Research Laboratories

US Patent
LigandPNGBDBM294373(US9586959, Compound 24 | US9586959, Compound 68 | ...)
Affinity DataIC50: 9.10E+3nMAssay Description:The binding assays of the human serotonin 3 receptor for present invention were performed at Cerep (Poitiers, France).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent