BDBM29490 Pyrazolo[1,5-a]-1,3,5-triazine, 13-15

SMILES CC[C@@H](C)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(OC)nc1C

InChI Key InChIKey=LBWQSAZEYIZZCE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 29490   

TargetCorticotropin-releasing factor receptor 1(Rat)
Bristol-Myers Squibb

LigandPNGBDBM29490(Pyrazolo[1,5-a]-1,3,5-triazine, 13-15)
Affinity DataIC50: 6.10nMpH: 7.2 T: 2°CAssay Description:Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor-binding protein(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM29490(Pyrazolo[1,5-a]-1,3,5-triazine, 13-15)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to CRF-binding protein (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM29490(Pyrazolo[1,5-a]-1,3,5-triazine, 13-15)
Affinity DataIC50: 6.10nMAssay Description:Antagonist activity at human CRF1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Rat)
Bristol-Myers Squibb

LigandPNGBDBM29490(Pyrazolo[1,5-a]-1,3,5-triazine, 13-15)
Affinity DataIC50: 6.10nMAssay Description:Displacement of [125I]-sauvagine from rat CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM29490(Pyrazolo[1,5-a]-1,3,5-triazine, 13-15)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes preincubated for 1 hr followed by compound washout for 2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2019
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM29490(Pyrazolo[1,5-a]-1,3,5-triazine, 13-15)
Affinity DataIC50: 340nMAssay Description:Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes preincubated for 1 hr followed by [125I]-CRF addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2019
Entry Details Article
PubMed