BDBM295021 US10112922, Compound 11

SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCN(C1)C(=O)\C=C/C(O)=O

InChI Key InChIKey=OROFFFJSAAWPDA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 295021   

TargetTyrosine-protein kinase BTK(Human)
Centaurus Biopharma

US Patent
LigandPNGBDBM295021(US10112922, Compound 11)
Affinity DataIC50: 100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
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TargetTyrosine-protein kinase ITK/TSK(Human)
Centaurus Biopharma

US Patent
LigandPNGBDBM295021(US10112922, Compound 11)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent