BDBM295023 US10112922, Compound 13

SMILES CC(=O)OC\C=C\C(=O)N1CC[C@H](C1)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=QMUHPTOKSUIGIA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 295023   

TargetTyrosine-protein kinase BTK(Human)
Centaurus Biopharma

US Patent
LigandPNGBDBM295023(US10112922, Compound 13)
Affinity DataIC50: 100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Centaurus Biopharma

US Patent
LigandPNGBDBM295023(US10112922, Compound 13)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent