BDBM295050 3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-(2-hydroxy-2-methylpropyl)-4-methylbenzenesulfonamide::US10112926, Example 6

SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O

InChI Key InChIKey=UQIUWUJYJBQZBY-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 295050   

LigandPNGBDBM295050(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50: 36nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandPNGBDBM295050(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using phosphatidylinositol as substrate incubated for 30 to 60 mins in presence of ATP by TR-FRET based Adap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM295050(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50: 120nMAssay Description:Inhibition of PI3Kgamma in human U937 cells assessed as reduction in AKT phosphorylation preincubated for 30 mins followed by MIP1alpha stimulation f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM295050(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using L-alpha-phosphatidylinositol as substrate incubated for 30 to 60 mins in presence of ATP by Kinase Glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM295050(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50: 400nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandPNGBDBM295050(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50: 620nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM295050(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Binding affinity to PDE4d (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM295050(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50: 2.30E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis

US Patent
LigandPNGBDBM295050(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50: 2.73E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM295050(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50: 6.25E+3nMAssay Description:Inhibition of human PI3Kalpha expressed in rat fibroblast cells assessed as reduction in AKT phosphorylation at Ser473 residue incubated for 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Novartis

US Patent
LigandPNGBDBM295050(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50: 6.85E+3nMpH: 7.5Assay Description:Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of interest. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandPNGBDBM295050(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent