BDBM295724 BDBM295851::US10112935, Compound A-24

SMILES Nc1cncc(c1)-c1nnc(Nc2ccc3[nH]ncc3c2)s1

InChI Key InChIKey=YHQLEOKWEREMAU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 295724   

TargetRho-associated protein kinase 1(Human)
Lycera

US Patent
LigandPNGBDBM295724(BDBM295851 | US10112935, Compound A-24)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:Assays for ROCK inhibition were performed using the following protein constructs: glutathione S-transferase (GST)-tagged human ROCK1 catalytic domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Lycera

US Patent
LigandPNGBDBM295724(BDBM295851 | US10112935, Compound A-24)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:Assays for ROCK inhibition were performed using the following protein constructs: glutathione S-transferase (GST)-tagged human ROCK1 catalytic domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Lycera

US Patent
LigandPNGBDBM295724(BDBM295851 | US10112935, Compound A-24)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:Assays for ROCK inhibition were performed using the following protein constructs: glutathione S-transferase (GST)-tagged human ROCK1 catalytic domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Lycera

US Patent
LigandPNGBDBM295724(BDBM295851 | US10112935, Compound A-24)
Affinity DataIC50: 8.00E+3nMT: 2°CAssay Description:Assays for ROCK inhibition were performed using the following protein constructs: glutathione S-transferase (GST)-tagged human ROCK1 catalytic domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent