BDBM295926 US10112935, Compound 50D

SMILES Clc1c(Nc2nnc(s2)-c2cccn3cc(nc23)-c2ccc(cc2)C#N)ccc2[nH]ncc12

InChI Key InChIKey=FLMHCINANYQSDB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 295926   

TargetRho-associated protein kinase 2(Human)
Lycera

US Patent
LigandPNGBDBM295926(US10112935, Compound 50D)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:Assays for ROCK inhibition were performed using the following protein constructs: glutathione S-transferase (GST)-tagged human ROCK1 catalytic domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Lycera

US Patent
LigandPNGBDBM295926(US10112935, Compound 50D)
Affinity DataIC50: 3.00E+4nMT: 2°CAssay Description:Assays for ROCK inhibition were performed using the following protein constructs: glutathione S-transferase (GST)-tagged human ROCK1 catalytic domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent