BDBM297225 2-[3-(Dimethyl-1H-1,2,3-triazol-5-yl)-5-[(1,3-dimethyl-1H-pyrazol-5-yl)(oxan-4-yl)methyl]-5H-pyrido[3,2-b]indol-7-yl]propan-2-ol::US10112941, Example 341

SMILES Cc1cc([C@H](C2CCOCC2)n2c3cc(ccc3c3ncc(cc23)-c2c(C)nnn2C)C(C)(C)O)n(C)n1

InChI Key InChIKey=MENGKLXMZRODAK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 297225   

TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM297225(US10112941, Example 341 | 2-[3-(Dimethyl-1H-1,2,3-...)
Affinity DataIC50: 5nMAssay Description:All assay components were dissolved in buffer composition 20 mM Hepes pH 7.5, 150 mM NaCl, 5 mM DTT, 0.005% Tween 20, and 100 ug/ml BSA for BRD4 (1-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM297225(US10112941, Example 341 | 2-[3-(Dimethyl-1H-1,2,3-...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM297225(US10112941, Example 341 | 2-[3-(Dimethyl-1H-1,2,3-...)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of BRD4 (unknown origin) assessed as reduction in c-Myc expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed