BDBM297411 4-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}bicyclo[2.2.2]octane-1-carboxylic acid::US10117864, Example 1::US10117864, Example 48::US10117864, Example 49::US10117864, Example 50::US10117864, Example 51

SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC12CCC(CC1)(CC2)C(O)=O)-c1ccccc1

InChI Key InChIKey=QZWSDSOAZQAJDD-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 297411   

TargetProstaglandin F2-alpha receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM297411(US10117864, Example 1 | US10117864, Example 49 | U...)
Affinity DataIC50: 74nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetProstaglandin F2-alpha receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM297411(US10117864, Example 1 | US10117864, Example 49 | U...)
Affinity DataIC50: 93nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetProstaglandin F2-alpha receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM297411(US10117864, Example 1 | US10117864, Example 49 | U...)
Affinity DataIC50: 91nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetProstaglandin F2-alpha receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM297411(US10117864, Example 1 | US10117864, Example 49 | U...)
Affinity DataIC50: 66nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetProstaglandin F2-alpha receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM297411(US10117864, Example 1 | US10117864, Example 49 | U...)
Affinity DataIC50: 93nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM297411(US10117864, Example 1 | US10117864, Example 49 | U...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 15 mins in presence of NADPH generating system by LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM297411(US10117864, Example 1 | US10117864, Example 49 | U...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 15 mins in presence of NADPH generating system by LC-MS/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM297411(US10117864, Example 1 | US10117864, Example 49 | U...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate incubated for 15 mins in presence of NADPH generating system by LC-MS/M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM297411(US10117864, Example 1 | US10117864, Example 49 | U...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 15 mins in presence of NADPH generating system by LC-MS/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM297411(US10117864, Example 1 | US10117864, Example 49 | U...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH generating system by LC-MS/MS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM297411(US10117864, Example 1 | US10117864, Example 49 | U...)
Affinity DataIC50: 68nMAssay Description:Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed