BDBM297574 1-{2-cyclopropyl-4-[4-(2-methoxy- phenyl)-piperidin-1-yl]- quinazolin-6-yl}-piperidin-4-ol::US10118902, Example 76::US10584103, Example 76

SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N1CCC(O)CC1)C1CC1

InChI Key InChIKey=KQOJNRJDNGMXQW-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 297574   

TargetNeurotensin receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM297574(US10118902, Example 76 | 1-{2-cyclopropyl-4-[4-(2-...)
Affinity DataEC50:  6.00E+3nMAssay Description:NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

TargetNeurotensin receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM297574(US10118902, Example 76 | 1-{2-cyclopropyl-4-[4-(2-...)
Affinity DataEC50:  6.00E+3nMAssay Description:NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetNeurotensin receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM297574(US10118902, Example 76 | 1-{2-cyclopropyl-4-[4-(2-...)
Affinity DataEC50:  6.72E+3nMAssay Description:Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed