BDBM298314 (E)-3-(4-(2-(2-fluoro-2-methylpropyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid (isomer 1)*::US10130617, Example 8

SMILES CC(C)(F)CN4C(c1ccc(/C=C/C(=O)O)cc1)c3[nH]c2ccccc2c3CC4(C)C

InChI Key InChIKey=RZLKPYCEHAUODL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 298314   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM298314((E)-3-(4-(2-(2-fluoro-2-methylpropyl)-3,3-dimethyl...)
Affinity DataIC50: 2.20E+3nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM298314((E)-3-(4-(2-(2-fluoro-2-methylpropyl)-3,3-dimethyl...)
Affinity DataIC50: 3.00E+3nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent