BDBM298341 4-[({3-[5-Chloro-2-(1H-tetrazol-1-yl)phenyl]-7-hydroxy-1-oxido-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl}carbonyl)amino]benzoic acid::US10123995, Example 19

SMILES CC(C)(C)OC(=O)c1ccc(NC(=O)C2(O)CCc3cc(cnc23)-c2cc(Cl)ccc2-n2cnnn2)cc1

InChI Key InChIKey=VXERMDCBSOMJCB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 298341   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM298341(US10123995, Example 19 | 4-[({3-[5-Chloro-2-(1H-te...)
Affinity DataIC50: 6nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM298341(US10123995, Example 19 | 4-[({3-[5-Chloro-2-(1H-te...)
Affinity DataIC50: 1.37E+3nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent