BDBM298393 4-[[4-[[4-[[5-tert-Butyl-3-(methanesulfonamido)-2-methoxy-phenyl]carbamoylamino]-1-naphthyl]oxy]-2-pyridyl]amino]-2-ethynyl-N-(2-morpholinoethyl)benzamide::US10125100, Example 15::US10392346, Example 15::US10941115, Example 15::US9751837, Example 15

SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(C(=O)NCCN5CCOCC5)c(c4)C#C)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C

InChI Key InChIKey=DQBWTIIAKDUFDY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 298393   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Topivert Pharma

US Patent
LigandPNGBDBM298393(US10125100, Example 15 | 4-[[4-[[4-[[5-tert-Butyl-...)
Affinity DataIC50: 43nMAssay Description:c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent

TargetBaculoviral IAP repeat-containing protein 2 [174-256](Human)
Topivert Pharma

US Patent
LigandPNGBDBM298393(US10125100, Example 15 | 4-[[4-[[4-[[5-tert-Butyl-...)
Affinity DataIC50: 64nMAssay Description:p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Topivert Pharma

US Patent
LigandPNGBDBM298393(US10125100, Example 15 | 4-[[4-[[4-[[5-tert-Butyl-...)
Affinity DataIC50: 163nMAssay Description:c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Topivert Pharma

US Patent
LigandPNGBDBM298393(US10125100, Example 15 | 4-[[4-[[4-[[5-tert-Butyl-...)
Affinity DataIC50: 2.79E+3nMAssay Description:GSK 3α Method 2: This method follows the same steps as Method 1, but utilises a shorter period of mixing of the test compound (105 minutes inste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent