BDBM299742 (E)-3-(3-fluoro-4-(2-((S)-3-fluoro-2-methylpropyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid (isomer 1)*::US10130617, Example 9

SMILES C[C@H](CF)CN4C(c1ccc(/C=C/C(=O)O)cc1F)c3[nH]c2ccccc2c3CC4(C)C

InChI Key InChIKey=IOPRLAHXDGSIHG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299742   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM299742((E)-3-(3-fluoro-4-(2-((S)-3-fluoro-2-methylpropyl)...)
Affinity DataIC50: 1.20E+3nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM299742((E)-3-(3-fluoro-4-(2-((S)-3-fluoro-2-methylpropyl)...)
Affinity DataIC50: 1.50E+3nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent