BDBM301032 4-(2-{[(3S)-pyrrolidin-3- ylmethyl]amino}-5-[4- (trifluoromethyl)phenyl]pyrimidin-4- yl)benzonitrile::US10131664, Example 25::US10543198, Example 25::US10864202, Example 25

SMILES N#Cc4ccc(c2nc(NC[C@H]1CCNC1)ncc2c3ccc(C(F)(F)F)cc3)cc4

InChI Key InChIKey=XLFAHCWFRUDOBL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 301032   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM301032(4-(2-{[(3S)-pyrrolidin-3- ylmethyl]amino}-5-[4- (t...)
Affinity DataIC50: 10nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM301032(4-(2-{[(3S)-pyrrolidin-3- ylmethyl]amino}-5-[4- (t...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM301032(4-(2-{[(3S)-pyrrolidin-3- ylmethyl]amino}-5-[4- (t...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
US Patent