BDBM304240 US10143695, Compound 7A

SMILES COc1ccc2n(ccc2c1)C(=O)c1cc(NC(=O)c2cc(NC(=O)c3nc(NC(=O)CCCOc4cc5N=C[C@@H]6CC(=C)CN6C(=O)c5cc4OC)cn3C)cn2C)cn1C

InChI Key InChIKey=AENWHNQSEDRFNL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 304240   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304240(US10143695, Compound 7A)
Affinity DataIC50: 0.600nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304240(US10143695, Compound 7A)
Affinity DataIC50: 0.150nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304240(US10143695, Compound 7A)
Affinity DataIC50: 0.300nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304240(US10143695, Compound 7A)
Affinity DataIC50: 1.10nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304240(US10143695, Compound 7A)
Affinity DataIC50: 2.70nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent