BDBM304253 US10143695, Compound 77

SMILES C=C1C[C@H]2C=Nc3cc(OCCCC(=O)Nc4cn(C)c(C(=O)Nc5cc(C(=O)Nc6cc(C(=O)N7CCc8cc(N)ccc87)n(C)c6)n(C)c5)n4)c(OC)cc3C(=O)N2C1

InChI Key InChIKey=DSDOQXRNSDQKAU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 304253   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 304253BDBM304253(US10143695, Compound 77)
Affinity DataIC50: 1.40nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 304253BDBM304253(US10143695, Compound 77)
Affinity DataIC50: 6.40nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 304253BDBM304253(US10143695, Compound 77)
Affinity DataIC50: 8.60nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 304253BDBM304253(US10143695, Compound 77)
Affinity DataIC50: 14.9nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 304253BDBM304253(US10143695, Compound 77)
Affinity DataIC50: 37.1nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent