BDBM304258 US10143695, Compound 84

SMILES Cn1cc(NC(=O)c2nc(NC(=O)CCCOc3cc4N=C[C@@H]5CC(=C)CN5C(=O)c4cc3O)cn2C)cc1C(=O)Nc1cnc2[nH]ccc2c1

InChI Key InChIKey=MXKRUSVUWUDHTE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 304258   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304258(US10143695, Compound 84)
Affinity DataIC50: 5.40nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304258(US10143695, Compound 84)
Affinity DataIC50: 0.660nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304258(US10143695, Compound 84)
Affinity DataIC50: 1.5nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304258(US10143695, Compound 84)
Affinity DataIC50: 3.60nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304258(US10143695, Compound 84)
Affinity DataIC50: 3.80nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent