BDBM305347 US10144734, Example 363::US10881652, Example 363

SMILES CCOc1cc(-c2ccc(nc2)N2C[C@H](N)[C@H](C2)Oc2ccc(OC)cn2)c2c(cnn2c1)C#N

InChI Key InChIKey=FNDLMBPWJRRKND-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 305347   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM305347(US10144734, Example 363 | US10881652, Example 363)
Affinity DataIC50: 5.5nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM305347(US10144734, Example 363 | US10881652, Example 363)
Affinity DataIC50: 5.5nMAssay Description:Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

LigandPNGBDBM305347(US10144734, Example 363 | US10881652, Example 363)
Affinity DataIC50: 22.7nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

LigandPNGBDBM305347(US10144734, Example 363 | US10881652, Example 363)
Affinity DataIC50: 22.7nMAssay Description:Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent

LigandPNGBDBM305347(US10144734, Example 363 | US10881652, Example 363)
Affinity DataIC50: 35nMAssay Description:The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

LigandPNGBDBM305347(US10144734, Example 363 | US10881652, Example 363)
Affinity DataIC50: 35nMAssay Description:The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
US Patent