BDBM3063 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 30::6-(2,6-Dichlorophenyl)-8-methyl-2-(3-morpholin-4-ylpropylamino)-8H-pyrido[2,3-d]pyrimidin-7-one::6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(morpholin-4-yl)propyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL48172::PD 166285 analog

SMILES Cn1c2nc(NCCCN3CCOCC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key InChIKey=CSLJSOAIJCEXMF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 3063   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3063(PD 166285 analog | 6-(2,6-dichlorophenyl)-8-methyl...)
Affinity DataIC50: 530nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM3063(PD 166285 analog | 6-(2,6-dichlorophenyl)-8-methyl...)
Affinity DataIC50: 530nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3063(PD 166285 analog | 6-(2,6-dichlorophenyl)-8-methyl...)
Affinity DataIC50: 1.41E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3063(PD 166285 analog | 6-(2,6-dichlorophenyl)-8-methyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM3063(PD 166285 analog | 6-(2,6-dichlorophenyl)-8-methyl...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibitory concentration of compound against mouse Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3063(PD 166285 analog | 6-(2,6-dichlorophenyl)-8-methyl...)
Affinity DataIC50: 6.80E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2005
Entry Details Article
PubMed