BDBM306581 (1R,8S)-N-[(6-amino-2,4- dimethylpyridin-3-yl)methyl]-12- [(2-oxo-1,2-dihydropyridin-1- yl)methyl]-15- oxatetracyclo[6.6.1.02,7.09,14]- pentadeca-2,4,6,9,11,13- hexaene-4-carboxamide::US10144746, Compound 224

SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2[C@H]3O[C@H](c4cc(Cn5ccccc5=O)ccc34)c2c1

InChI Key InChIKey=XQTFRVXONVZEHH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306581   

TargetPlasma kallikrein(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM306581(US10144746, Compound 224 | (1R,8S)-N-[(6-amino-2,4...)
Affinity DataIC50: 1nMAssay Description:The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
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