BDBM306604 (1R,8S)-N-{[6-amino-2-methyl-4- (oxan-4-yl)pyridin-3- yl]methyl)-12-(2,4- difluorophenyl)-15- oxatetracyclo[6.6.1.02,7.09,14] pentadeca-2,4,6,9,11,13- hexaene-4-carboxamide::US10144746, Compound 247

SMILES Cc1nc(N)cc(C2CCOCC2)c1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-c1ccc(F)cc1F

InChI Key InChIKey=SGLCEUPAXRNQPL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306604   

TargetPlasma kallikrein(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM306604(US10144746, Compound 247 | (1R,8S)-N-{[6-amino-2-m...)
Affinity DataIC50: 5.01nMAssay Description:The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
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