BDBM309348 (S)-N-(1-((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)amino)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)cyclopropanecarboxamide::US9656959, Example 33

SMILES Fc1ccc(Oc2ccc(cc2)-c2cccc(NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)C3CC3)n2)cc1

InChI Key InChIKey=WSKHJOJDBIXEBG-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 309348   

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM309348(US9656959, Example 33 | (S)-N-(1-((6-(4-(4-fluorop...)
Affinity DataIC50: 110nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM309348(US9656959, Example 33 | (S)-N-(1-((6-(4-(4-fluorop...)
Affinity DataKi:  206nMAssay Description:In the alternative, the voltage clamp protocol to examine hNav1.7 currents was as follows. First, the standard current-voltage relationship was teste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent