BDBM310879 2-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-5,7,7a,8,9,10-hexahydropyrrolo[2,1-d][1,5]benzodiazepin-6-one::US10150767, Example 15

SMILES Cn1cc(C2CC3C=CNN3C3C(CCCC3=O)N2)c2cc[nH]c2c1=O

InChI Key InChIKey=HEYORHGJPVTIJW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 310879   

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM310879(US10150767, Example 15 | 2-(6-methyl-7-oxo-1H-pyrr...)
Affinity DataIC50: 81nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent