BDBM310947 US10155722, Example 28

SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(CNC(=O)C3CC3)ccc2-c2ccsc2)c1

InChI Key InChIKey=ROHGHHXPPRHUBP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 310947   

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM310947(US10155722, Example 28)
Affinity DataIC50: 55nMAssay Description:The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent