BDBM311245 (S)-6-((2-amino-2,4-dimethylpentyl)oxy)-2′-methyl-[3,4′-bipyridine]-5-carbonitrile::US10155760, Example 101::US10351563, Example 101::US10544120, Example 101::US10723734, Example 101::US10981910, Example 101::US9902722, Example 101

SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C#N)-c1ccnc(C)c1

InChI Key InChIKey=UMBMFKNLBDNBNH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 311245   

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311245(US10155760, Example 101 | (S)-6-((2-amino-2,4-dime...)
Affinity DataIC50: 27nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
Go to US Patent

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311245(US10155760, Example 101 | (S)-6-((2-amino-2,4-dime...)
Affinity DataIC50: 27nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311245(US10155760, Example 101 | (S)-6-((2-amino-2,4-dime...)
Affinity DataIC50: 27nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
Go to US Patent

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311245(US10155760, Example 101 | (S)-6-((2-amino-2,4-dime...)
Affinity DataIC50: 27nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311245(US10155760, Example 101 | (S)-6-((2-amino-2,4-dime...)
Affinity DataIC50: 27nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 Cl prepared from 15 μl additions of enzyme and substrates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
Go to US Patent

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311245(US10155760, Example 101 | (S)-6-((2-amino-2,4-dime...)
Affinity DataIC50: 27nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311245(US10155760, Example 101 | (S)-6-((2-amino-2,4-dime...)
Affinity DataIC50: 22nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed