BDBM311555 N-(5-tert-butyl-2- carbamoylthiophen-3- yl)pyrazolo[1,5- a]pyrimidine-3-carboxamide hydrochloride::US10155765, Example 51

SMILES CC(C)(C)c1cc(NC(=O)c2cnn3cccnc23)c(s1)C(N)=O

InChI Key InChIKey=HHAIGVLEWUCEQW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311555   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM311555(US10155765, Example 51 | N-(5-tert-butyl-2- carbam...)
Affinity DataIC50: 254nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
US Patent