BDBM311564 2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(3-carbamoyl-1- ethyl-1H-pyrazol-4- yl)pyrrolo[2,1- f][1,2,41triazine-7- carboxamide trifluoroacetate::US10155765, Example 62

SMILES CCn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(n1)C(N)=O

InChI Key InChIKey=YGAODTUHZWIDAG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311564   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM311564(US10155765, Example 62 | 2-{[(1R,2S)-2- aminocyclo...)
Affinity DataIC50: 1nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2019
Entry Details
US Patent