BDBM312218 US9604926, Compound CM-728::US9724435, Compound CM728

SMILES Fc1ccc(cc1)N1CCN(CCCCn2c3ccccc3[nH]c2=O)CC1

InChI Key InChIKey=OEIIOVCBHYALEP-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 312218   

TargetSigma intracellular receptor 2(Rat)
University of Florida

Curated by ChEMBL
LigandPNGBDBM312218(US9604926, Compound CM-728 | US9724435, Compound C...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-DTG from sigma2 receptor in rat brain membranes after 120 mins in presence of (+)-pentazocine by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
University of Florida

Curated by ChEMBL
LigandPNGBDBM312218(US9604926, Compound CM-728 | US9724435, Compound C...)
Affinity DataKi:  29.6nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetSigma intracellular receptor 2(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312218(US9604926, Compound CM-728 | US9724435, Compound C...)
Affinity DataKi:  29.6nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Rat)
University of Florida

Curated by ChEMBL
LigandPNGBDBM312218(US9604926, Compound CM-728 | US9724435, Compound C...)
Affinity DataKi:  144nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in rat brain membranes after 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM312218(US9604926, Compound CM-728 | US9724435, Compound C...)
Affinity DataKi:  186nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Rat)
University of Florida

Curated by ChEMBL
LigandPNGBDBM312218(US9604926, Compound CM-728 | US9724435, Compound C...)
Affinity DataKi:  1.86E+3nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent