BDBM312243 1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one::US10016430, Example 6::US11000525, Example 6::US9616063, 6

SMILES CCNCc1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S

InChI Key InChIKey=JZRGPABFYJPXQJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 312243   

TargetMyeloperoxidase(Human)
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50: 22nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2019
Entry Details
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TargetThyroid peroxidase(Human)
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50: 1.00E+4nMAssay Description:To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2019
Entry Details
Go to US Patent

TargetMyeloperoxidase(Human)
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50: 22nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetThyroid peroxidase(Human)
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50: 1.00E+4nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetMyeloperoxidase(Human)
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50: 22nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetThyroid peroxidase(Human)
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent