BDBM316509 2-({(3R,6R)-1-[(6-methoxy-2- pyrimidin-2-ylpyridin-3-yl)carbonyl]- 6-methylpiperidin-3- yl}sulfanyl)pyridine-4-carbonitrile::US9617246, 43

SMILES COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)Sc2cc(ccn2)C#N)c(n1)-c1ncccn1

InChI Key InChIKey=WNKQSHFWORJJHF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 316509   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316509(2-({(3R,6R)-1-[(6-methoxy-2- pyrimidin-2-ylpyridin...)
Affinity DataIC50: 864nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316509(2-({(3R,6R)-1-[(6-methoxy-2- pyrimidin-2-ylpyridin...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent