BDBM318221 BDBM318359::US10301317, Example 177::US9624228, Example 177

SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCC[C@@H](C1)NCc1ccccc1

InChI Key InChIKey=PUNLKTQAEVDJOW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318221   

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandPNGBDBM318221(BDBM318359 | US9624228, Example 177 | US10301317, ...)
Affinity DataIC50: 50nMAssay Description:The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandPNGBDBM318221(BDBM318359 | US9624228, Example 177 | US10301317, ...)
Affinity DataIC50: 50nMAssay Description:The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandPNGBDBM318221(BDBM318359 | US9624228, Example 177 | US10301317, ...)
Affinity DataIC50: 50nMAssay Description:The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent