BDBM31853 2,4-Bisanilinopyrimidine, 18

SMILES Oc1ccc(Nc2ncc(F)c(Nc3ccc(O)cc3)n2)cc1

InChI Key InChIKey=VRCCTIYIKPFOBO-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 31853   

TargetAurora kinase A(Human)
Genentech

LigandPNGBDBM31853(2,4-Bisanilinopyrimidine, 18)
Affinity DataIC50: 30nMAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM31853(2,4-Bisanilinopyrimidine, 18)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed