BDBM320117 3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 284::US10202369, Example 284::US10472354, Example 284

SMILES CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F

InChI Key InChIKey=IDFXYIYQWCENGA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 320117   

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320117(US10174016, Example 284 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 4nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
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TargetP2X purinoceptor 2(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320117(US10174016, Example 284 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 57nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320117(US10174016, Example 284 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 4nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 2(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320117(US10174016, Example 284 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 57nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320117(US10174016, Example 284 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 4nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 2/3(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320117(US10174016, Example 284 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 57nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320117(US10174016, Example 284 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 4nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 2/3(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320117(US10174016, Example 284 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 57nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
Go to US Patent