BDBM320163 3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 330::US10472354, Example 334

SMILES C[C@@H](NC(=O)c1cc(OC[C@@]2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F

InChI Key InChIKey=LFYNTNZWPQXJEM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 320163   

TargetP2X purinoceptor 3(Human)
Beyer Aktiengesellschaft

US Patent
LigandPNGBDBM320163(US10174016, Example 330 | 3-[(2-methyltetrahydrofu...)
Affinity DataIC50: 5nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetP2X purinoceptor 2(Human)
Beyer Aktiengesellschaft

US Patent
LigandPNGBDBM320163(US10174016, Example 330 | 3-[(2-methyltetrahydrofu...)
Affinity DataIC50: 170nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 3(Human)
Beyer Aktiengesellschaft

US Patent
LigandPNGBDBM320163(US10174016, Example 330 | 3-[(2-methyltetrahydrofu...)
Affinity DataIC50: 7nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 2/3(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320163(US10174016, Example 330 | 3-[(2-methyltetrahydrofu...)
Affinity DataIC50: 191nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 3(Human)
Beyer Aktiengesellschaft

US Patent
LigandPNGBDBM320163(US10174016, Example 330 | 3-[(2-methyltetrahydrofu...)
Affinity DataIC50: 4nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 2/3(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320163(US10174016, Example 330 | 3-[(2-methyltetrahydrofu...)
Affinity DataIC50: 132nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
Go to US Patent